Life, Genes & You
Knowledge of our genetic code has radically altered our
understanding of our lives.
Just as there was a 19th-century Darwinian revolution which
transformed how humans viewed themselves and their place in the
world, the late 20th century has seen a revolution changing our
perceptions of who we are, where we came from and how we relate to
other humans and to other species on our planet.
Genes and genetics have been widely taken up in western public
discourse as explanatory and inspirational symbols, but the science
of genetics moves exceptionally fast, not just in terms of
technical details but also in the far-reaching social and medical
implications of what is revealed. It is essential that scientists
are able to communicate new developments accurately and clearly,
which has not always been the case. Media focus on the negative
aspects of genetic discoveries results in scare stories about
'designer babies' and cloning. Failure to highlight the time lag
between the discovery of a disease-related gene and the development
of tests and treatment for the disease can raise false hopes in
sufferers from that disease or their families.
The increasing dominance of genetics in public discourse in the
last decade could result in a shift towards us viewing ourselves in
a way that is completely genetic, a tendency to look to our genes
to explain everything about who we are. The debate over what our
children inherit from us, and what impact environment and
conditioning have on them - which used to be known as the nature
versus nurture debate - is now understood in terms of DNA. But it
is the complex interactions that take place between our DNA and the
environment that make us who we are, not solely our genes.
Discoveries in the field of genetics have not just had a
profound impact on our perception of ourselves, but on our
conceptualizations of human difference and how we relate to other
human beings. The role of race in human genetics is hugely
controversial but it is clear that what is called 'race', although
culturally important, reflects just a few continuous traits
determined by a fraction of our genes. From the perspective of
genes, it is the case that the great majority of genetic variation
is between individuals rather than races. Two people from the same
region who look superficially alike can be less related to each
other than they are to people from other parts of the world who may
look very different.
Genetic research has also appeared to blur and shrink the
difference between humans and other mammals. We are frequently
reminded that we share between 94 and 98 per cent of our genes with
our closest living ancestors, chimpanzees. Although this reinforces
Darwin's theory about our close relationship to the apes, which
shocked Victorian society, it also usefully illustrates the
complexity of our genetic programming and how small variations - in
this case between 6 and 2 per cent - can make literally a world of
difference. Comparing chimp and human genomes can also shed light
on the past six million years or so of evolution, since the two
species diverged from an apelike common ancestor.
The mapping of the human genome could have re-fashioned our
perceptions of ourselves in a rather sterile and utilitarian way,
reducing us to chemical assemblages that temporarily stabilise DNA
for the duration of the human life span. This would make humans
merely the sum of our genes, a development that has been referred
to as 'geneticisation'. In fact, advances in genetics understanding
have served to underline the immense complexity and wonder of the
human being. Scientists struggling to explain to the public the
extraordinary discoveries they are making in scientific language
are forced to use metaphors and analogies, sometimes almost poetic,
to convey their complexity and scale. Thus Francis Collins, the
leader of the US Human Genome Project, described the results of the
project as "the first draft of the human book of life…the first
glimpse of our own instruction book".